Prescribing Information, including Boxed WARNING                          For Healthcare Professionals
IMPORTANT SAFETY INFORMATION for AVANDIA® (rosiglitazone maleate)
AVANDIA can cause or worsen heart failure. If you have severe heart failure (very poor pumping ability of the heart), you cannot be started on AVANDIA (see Boxed WARNING).
SAFETY INFORMATION CONTINUED BELOW 
AVANDIA rosiglitazone maleate | Diabetes Medication
Low Blood Sugar
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Low Blood Sugar

Low blood sugar (hypoglycemia) happens when you don’t eat enough or often enough. It may also happen if you exercise more than you usually do, take too much of your diabetes medicine(s), or drink alcohol. A low blood sugar reading is 70 mg/dL or below.

How do you know if you may have low blood sugar? Here are some symptoms:

  • Confusion 
  • Dizziness or light-headedness
  • Feeling anxious or weak 
  • Hunger
  • Nervousness and shakiness
  • Sleepiness 
  • Sweating
  • Trouble speaking

You should talk to your doctor to find out the normal blood sugar level for you and tell your doctor if you are experiencing any of these symptoms.

If you have any of these symptoms, test your blood sugar with your at-home glucose meter.

What You Can Do If You Have Low Blood Sugar

As recommended by the 2009 American Diabetes Association guidelines, if you have low blood sugar, eat or drink a small amount of something that has sugar. Examples are two or three glucose tablets that you can buy at the pharmacy, or 1/2 cup of fruit juice.

As recommended by the 2009 American Diabetes Association guidelines, after 15 minutes, test your blood sugar again. If you still have low blood sugar, or you still have symptoms, have another small amount of something that has sugar. Wait 15 minutes and test again. Once your blood sugar levels have recovered, you should eat a meal or snack. This may help prevent additional low blood sugar. If you have low blood sugar several times a week, call your doctor.

If you are having symptoms but your meter shows that your blood sugar is fine, follow the steps above to recheck your blood sugar. Your meter might not be working right.

DO NOT DRIVE while you have low blood sugar or symptoms of low blood sugar.

When you test your blood sugar at home, you can use the Blood Sugar Tracker (PDF) to write down your results.  Share your blood sugar control records with your doctor.

*Only your doctor can decide if AVANDIA is right for you. AVANDIA is not right for everyone.
Taking AVANDIA with insulin or nitrates is not recommended.

IMPORTANT SAFETY INFORMATION for AVANDIA® (rosiglitazone maleate)

AVANDIA can cause or worsen heart failure. If you have severe heart failure (very poor pumping ability of the heart) you cannot be started on AVANDIA. AVANDIA is also not recommended if you have heart failure with symptoms (such as shortness of breath or swelling), even if these symptoms are not severe.

AVANDIA may increase your risk of other heart problems that occur when there is reduced blood flow to the heart, such as chest pain (angina) or heart attack (myocardial infarction). This risk appeared higher in patients taking medicines called nitrates or insulin.

If you have chest pain or a feeling of chest pressure, you should seek immediate medical attention, regardless of what diabetes medicines you are taking. If you take AVANDIA, tell your doctor right away if you have swollen legs or ankles, a rapid increase in weight or difficulty breathing, or unusual tiredness; experience changes in vision; become pregnant.

Before taking AVANDIA, review your medical history and tell your doctor if you:

Women taking AVANDIA should know that AVANDIA may increase the risk of pregnancy. More fractures have been observed in women taking AVANDIA. Other possible side effects of AVANDIA include anemia and hypoglycemia. Your doctor should do blood tests to check your liver before you start AVANDIA and during treatment as needed.

Prescription AVANDIA, along with diet and exercise, helps improve blood sugar control in adults with type 2 diabetes.

For more information about AVANDIA, please see Medication Guide and full Prescribing Information, including Boxed WARNING.