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    • AVANDIA rosiglitazone maleate | Diabetes Medication
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    Healthcare Associations

    For more information on ways to help manage your diabetes, you may want to visit these websites:

    American Association of Clinical Endocrinologists is a professional community of clinical endocrinologists that is committed to transforming the lives of patients by supporting leading-edge, ethical, and cost-effective medicine.

    American Association of Diabetes Educators is a multi-disciplinary professional membership organization dedicated to advancing the practice of diabetes self-management training and care.

    American College of Cardiology is an advocate for quality cardiovascular (heart and blood vessels) care.

    American Diabetes Association is a nonprofit health organization providing diabetes research, information and advocacy.

    American Heart Association is a nonprofit organization committed to reducing disability and death from cardiovascular diseases and stroke.

    American Kidney Fund is a voluntary health organization serving people with and at risk for kidney disease through direct financial assistance, comprehensive education, clinical research and community service programs.

    Association of Black Cardiologists is a nonprofit organization dedicated to eliminating the disparities related to cardiovascular disease in people of color.

    Centers for Disease Control and Prevention: Diabetes is a federal agency that protects the health and safety of people with diabetes via prevention activities and diabetes management. You'll find FAQs on diabetes plus links to important websites.

    Joslin Diabetes Center is a diabetes institution with efforts in scientific discovery, clinical care models, and educational strategies.

    National Diabetes Education Program is a federally funded program sponsored by the U.S. Department of Health and Human Services' National Institutes of Health and the Centers for Disease Control and Prevention and includes over 200 partners at the federal, state, and local levels, working together to reduce the morbidity and mortality associated with diabetes.

    National Diabetes Information Clearinghouse is an informational website that includes an extensive list of Topics and Titles-from your risk of diabetes to clinical trials and treatments.

    National Institute of Diabetes & Digestive & Kidney Diseases is a federal agency that provides information on research projects and clinical trials that have improved the quality of life for people with diabetes.

    Taking Control of Your Diabetes is a nonprofit organization dedicated to educating and motivating people with diabetes and their loved ones to take a more active role in their condition, in order to live healthier, happier, and more productive lives.

    The Diabetic Gourmet is an online magazine dedicated to diabetes-related health issues as well as diabetic dining and cooking information.

    This site contains links to third-party websites on the Internet. These links are provided as a service to individuals interested in diabetes. These sites are not part of this GlaxoSmithKline website. The content and materials in these third-party websites are not produced or endorsed by GlaxoSmithKline and may refer to uses of our products that are not recommended by GlaxoSmithKline. You should always consult with your physician or healthcare professional before using any GlaxoSmithKline prescription product.




    Please see important safety information below for AVANDIA, AVANDAMET and AVANDARYL, including who should not take AVANDIA, AVANDAMET or AVANDARYL. See also link to Medication Guides for AVANDIA, AVANDAMET and AVANDARYL.

    AVANDIA (rosiglitazone maleate)

    Prescription AVANDIA, along with diet and exercise, helps improve blood sugar control in adults with type 2 diabetes. Taking AVANDIA with insulin or nitrates is not recommended.

    AVANDIA can cause or worsen heart failure. If you have severe heart failure (very poor pumping ability of the heart) you cannot be started on AVANDIA. AVANDIA is also not recommended if you have heart failure with symptoms (such as shortness of breath or swelling) even if these symptoms are not severe.

    AVANDIA may increase your risk of other heart problems that occur when there is reduced blood flow to the heart, such as chest pain (angina) or heart attack (myocardial infarction). This risk appeared higher in patients taking medicines called nitrates or insulin.

    If you have chest pain or a feeling of chest pressure, you should seek immediate medical attention, regardless of what diabetes medicines you are taking. If you take AVANDIA, tell your doctor right away if you: have swollen legs or ankles, a rapid increase in weight or difficulty breathing, or unusual tiredness; experience changes in vision; become pregnant.

    Before taking AVANDIA, review your medical history and tell your doctor if you:

    • Have heart failure or other heart problems, or are on any medicines for high blood pressure, high cholesterol or heart failure, or for prevention of heart disease or stroke.
    • Take insulin or nitrate medicines.
    • Have a type of diabetic eye disease called macular edema.
    • Have liver problems or had liver problems while taking REZULIN® (troglitazone).
    • Are pregnant or planning to become pregnant.
    • Are breastfeeding or planning to breastfeed.

    Women taking AVANDIA should know that AVANDIA may increase the risk of pregnancy. More fractures have been observed in women taking AVANDIA. Other possible side effects of AVANDIA include anemia and hypoglycemia. Your doctor should do blood tests to check your liver before you start AVANDIA and during treatment as needed.

    For more information about AVANDIA, please see Medication Guide. For further information on AVANDIA, please see full Prescribing Information.

    AVANDAMET (rosiglitazone maleate/metformin HCl)

    Prescription AVANDAMET, along with diet and exercise, helps improve blood sugar control in patients with type 2 diabetes. It is a combination of two drugs - rosiglitazone maleate and metformin HCl. Taking AVANDAMET with insulin or nitrates is not recommended.

    AVANDAMET can cause or worsen heart failure. If you have severe heart failure (very poor pumping ability of the heart), you cannot be started on AVANDAMET. AVANDAMET is also not recommended if you have heart failure with symptoms (such as shortness of breath or swelling), even if these symptoms are not severe.

    Rosiglitazone, one of the medicines in AVANDAMET, may increase your risk of other heart problems that occur when there is reduced blood flow to the heart, such as chest pain (angina) or heart attack (myocardial infarction). This risk appeared higher in patients taking medicines called nitrates or insulin.

    If you have chest pain or a feeling of chest pressure, you should seek immediate medical attention, regardless of what diabetes medicines you are taking. If you take AVANDAMET, tell your doctor right away if you: have swollen legs or ankles, a rapid increase in weight or difficulty breathing, or unusual tiredness; experience changes in vision; become pregnant.

    A small number of people who have taken metformin, another medicine in AVANDAMET, have developed a rare yet serious condition called lactic acidosis (a buildup of lactic acid in the blood) that can cause death. You have a higher chance of getting lactic acidosis if you have kidney problems; have liver problems; drink alcohol very often or excessively; get dehydrated, as when you are sick with a fever, vomiting or diarrhea; or you are going to have surgery. Tell your doctor if you have any of these problems before or while taking AVANDAMET. You should not take AVANDAMET if you have kidney problems or metabolic acidosis. Tests should be used to check your kidneys and liver before and while taking AVANDAMET. If you are taking medicines for heart failure, you may be at increased risk of lactic acidosis.

    Call your doctor right away if you feel any of the following, which may be signs of lactic acidosis: very weak or tired; you have unusual (not normal) muscle pain; you have stomach pains; you have trouble breathing; you feel dizzy or lightheaded; or you have a slow or irregular heartbeat.

    Before taking AVANDAMET, review your medical history and tell your doctor if you:

    • Have heart failure or other heart problems, or are on any medicines for high blood pressure, high cholesterol or heart failure, or for prevention of heart disease or stroke.
    • Take insulin or nitrate medicines.
    • Have kidney problems.
    • Are going to have dye injected into a vein for an X-ray, CAT scan, heart study, or other type of scanning.
    • Drink a lot of alcohol.
    • Develop a serious condition such as a heart attack, severe infection, or a stroke.
    • Are 80 years of age or older.
    • Have a type of diabetic eye disease called macular edema.
    • Have liver problems or had liver problems while taking REZULIN® (troglitazone).
    • Are pregnant or planning to become pregnant.
    • Are breastfeeding or planning to breastfeed.

    Women taking AVANDAMET should know that AVANDAMET may increase the risk of pregnancy. More fractures have been observed in women taking AVANDAMET. Other possible side effects of AVANDAMET include anemia, hypoglycemia, diarrhea, nausea, and upset stomach. Your doctor should do blood tests to check your liver before you start AVANDAMET and during treatment as needed.

    For more information about AVANDAMET, please see Medication Guide. For further information on AVANDAMET, please see full Prescribing Information.

    AVANDARYL (rosiglitazone maleate and glimepiride)

    Prescription AVANDARYL, along with diet and exercise, helps improve blood sugar control in patients with type 2 diabetes. AVANDARYL is a combination of two drugs - rosiglitazone maleate and glimepiride. Taking rosiglitazone with insulin or with nitrates is not recommended.

    AVANDARYL can cause or worsen heart failure. If you have severe heart failure (very poor pumping ability of the heart), you cannot be started on AVANDARYL. AVANDARYL is also not recommended if you have heart failure with symptoms (such as shortness of breath or swelling), even if these symptoms are not severe.

    Rosiglitazone, one of the medicines in AVANDARYL, may increase your risk of other heart problems that occur when there is reduced blood flow to the heart, such as chest pain (angina) or heart attack (myocardial infarction). This risk appeared higher in patients taking medicines called nitrates or insulin.

    If you have chest pain or a feeling of chest pressure, you should seek immediate medical attention, regardless of what diabetes medicines you are taking. If you take AVANDARYL, tell your doctor right away if you: have swollen legs or ankles, a rapid increase in weight or difficulty breathing, or unusual tiredness; experience changes in vision; become pregnant.

    AVANDARYL may cause low blood sugar. Lightheadedness, dizziness, shakiness or hunger may mean that your blood sugar is too low. If you have kidney problems, you may need a lower dose of AVANDARYL to reduce problems with low blood sugar. Talk to your doctor if low blood sugar is a problem for you.

    Before taking AVANDARYL, review your medical history and tell your doctor if you:

    • Have heart failure or other heart problems, or are on any medicines for high blood pressure, high cholesterol or heart failure, or for prevention of heart disease or stroke.
    • Take insulin or nitrate medicines.
    • Have a type of diabetic eye disease called macular edema.
    • Have liver problems or had liver problems while taking REZULIN® (troglitazone).
    • Are pregnant or planning to become pregnant.
    • Are breastfeeding or planning to breastfeed.

    Women taking AVANDARYL should know that AVANDARYL may increase the risk of pregnancy. More fractures have been observed in women taking AVANDARYL. Another possible side effect of AVANDARYL is anemia. Your doctor should do blood tests to check your liver before you start AVANDARYL and during treatment as needed.

    For more information about AVANDARYL, please see Medication Guide. For further information on AVANDARYL, please see full Prescribing Information.