Prescribing Information, including Boxed WARNING                          For Healthcare Professionals
IMPORTANT SAFETY INFORMATION for AVANDIA® (rosiglitazone maleate)
AVANDIA can cause or worsen heart failure. If you have severe heart failure (very poor pumping ability of the heart), you cannot be started on AVANDIA (see Boxed WARNING).
SAFETY INFORMATION CONTINUED BELOW 
AVANDIA rosiglitazone maleate | Diabetes Medication
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How AVANDIA Works

AVANDIA works differently than some other diabetes medicines. It does not cause your body to make more insulin. Instead, AVANDIA helps your body use its own natural insulin better - for improved blood sugar control.*

AVANDIA, along with diet and exercise, can be taken alone or in combination with other diabetes pills to help improve blood sugar control - but taking AVANDIA when using insulin or nitrates is not recommended.

If your blood sugar is too high, your chance of having diabetes-related problems later is higher. Some of these diabetes complications are

AVANDIA is not indicated for the treatment of diabetes-related complications. AVANDIA is prescribed alone or with other diabetes medicines. Many people need to take more than one medicine to help treat diabetes in different ways. If AVANDIA is right for you, join the AVANDIA Savings Program to get a 30-day trial and up to $25 off your next three refills.

Since 2002, AVANDIA has been used by nearly 5 million people with type 2 diabetes. It is the most studied medicine for type 2 diabetes (See the GSK Clinical Trial Register for details on GSK's clinical studies research, including research on AVANDIA.)

*Individual results may vary.

*Only your doctor can decide if AVANDIA is right for you. AVANDIA is not right for everyone.
Taking AVANDIA with insulin or nitrates is not recommended.

IMPORTANT SAFETY INFORMATION for AVANDIA® (rosiglitazone maleate)

AVANDIA can cause or worsen heart failure. If you have severe heart failure (very poor pumping ability of the heart) you cannot be started on AVANDIA. AVANDIA is also not recommended if you have heart failure with symptoms (such as shortness of breath or swelling), even if these symptoms are not severe.

AVANDIA may increase your risk of other heart problems that occur when there is reduced blood flow to the heart, such as chest pain (angina) or heart attack (myocardial infarction). This risk appeared higher in patients taking medicines called nitrates or insulin.

If you have chest pain or a feeling of chest pressure, you should seek immediate medical attention, regardless of what diabetes medicines you are taking. If you take AVANDIA, tell your doctor right away if you have swollen legs or ankles, a rapid increase in weight or difficulty breathing, or unusual tiredness; experience changes in vision; become pregnant.

Before taking AVANDIA, review your medical history and tell your doctor if you:

Women taking AVANDIA should know that AVANDIA may increase the risk of pregnancy. More fractures have been observed in women taking AVANDIA. Other possible side effects of AVANDIA include anemia and hypoglycemia. Your doctor should do blood tests to check your liver before you start AVANDIA and during treatment as needed.

Prescription AVANDIA, along with diet and exercise, helps improve blood sugar control in adults with type 2 diabetes.

For more information about AVANDIA, please see Medication Guide and full Prescribing Information, including Boxed WARNING.